Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells
Figure 5
Increased immunoprecipitation of IGF-IR and Shc with in cells exposed to -estradiol . (a) Interactions between IGF-IR and Shc with ER in UtLM cells were determined by immunoprecipitation (IP). (b) Comparison of densitometric band intensity of immunoblots (IB) in UtLM cells with siScr or siIGF-IR followed by E2 treatment. Representative of three independent experiments. Bars represent mean intensities ± SEM. * versus 0 min.
