TY - JOUR
A2 - Matter, Karl
AU - Gui, Ting
AU - Sun, Yujing
AU - Shimokado, Aiko
AU - Muragaki, Yasuteru
PY - 2012
DA - 2012/01/29
TI - The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition
SP - 289243
VL - 2012
AB - The mitogen-activated protein kinase (MAPK) pathway allows cells to interpret external signals and respond appropriately, especially during the epithelial-mesenchymal transition (EMT). EMT is an important process during embryonic development, fibrosis, and tumor progression in which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced intercellular adhesion and increased motility. TGF-β signaling is the first pathway to be described as an inducer of EMT, and its relationship with the Smad family is already well characterized. Studies of four members of the MAPK family in different biological systems have shown that the MAPK and TGF-β signaling pathways interact with each other and have a synergistic effect on the secretion of additional growth factors and cytokines that in turn promote EMT. In this paper, we present background on the regulation and function of MAPKs and their cascades, highlight the mechanisms of MAPK crosstalk with TGF-β signaling, and discuss the roles of MAPKs in EMT.
SN - 2090-1739
UR - https://doi.org/10.1155/2012/289243
DO - 10.1155/2012/289243
JF - Journal of Signal Transduction
PB - Hindawi Publishing Corporation
KW -
ER -