Focal Adhesion Kinases in Adhesion Structures and Disease

Table 2

Signaling proteins and their link to adhesion structures and disease. ⁺Humans mutations are associated with disease. Mutations in dynamin are linked to centronuclear myopathy and Charcot-Marie-Tooth neuropathy in humans. ^*Bone mass regulation is based on knockout mice studies. Other disease indications are predicted based on animal studies and in vitro studies. n/d: not determined. See text for details.

Adhesion protein	Cell type	Adhesion structure	Disease indication
FAK	osteoblasts	focal adhesions	regulation of bone density^*
	osteoclasts	podosomes	regulation of bone density^*
	endothelial cells	podosomes?	angiogenesis
	lung carcinoma cells	podosomes	cancer metastasis
	various cancer cells	invadopodia	cancer metastasis
Pyk2	osteoblasts	focal adhesions	regulation of bone density^*
	osteoclasts	podosomes	regulation of bone density^*
	endothelial cells	podosomes?	angiogenesis
	various cancer cells	invadopodia	cancer metastasis
Src	osteoblasts	focal adhesions	regulation of bone density^*
	osteoclasts	podosomes	regulation of bone density^*
	various cancer cells	invadopodia	cancer metastasis
Dynamin	fibroblasts	focal adhesions	n/d
	osteoblasts	focal adhesions	regulation of bone density^*
	osteoclasts	podosomes	regulation of bone density^*
	neurons	n/d	neuropathy^+
Twist1	epithelial cells	invadopodia	cancer metastasis
TKS4/5	human cancer cells	invadopodia	cancer metastasis
Leupaxin	osteoclasts	podosomes	regulation of bone density^*
	cancer cells	invadopodia	cancer metastasis
Fgd1	osteoblasts	focal adhesions?	skeletal abnormalities^+
	cancer cells	invadopodia	prostate and breast cancer metastasis