TY - JOUR A2 - García-Sáinz, J. Adolfo AU - Vigneswara, Vasanthy AU - Kundi, Sarina AU - Ahmed, Zubair PY - 2012 DA - 2012/07/16 TI - Receptor Tyrosine Kinases: Molecular Switches Regulating CNS Axon Regeneration SP - 361721 VL - 2012 AB - The poor or lack of injured adult central nervous system (CNS) axon regeneration results in devastating consequences and poor functional recovery. The interplay between the intrinsic and extrinsic factors contributes to robust inhibition of axon regeneration of injured CNS neurons. The insufficient or lack of trophic support for injured neurons is considered as one of the major obstacles contributing to their failure to survive and regrow their axons after injury. In the CNS, many of the signalling pathways associated with neuronal survival and axon regeneration are regulated by several classes of receptor tyrosine kinases (RTK) that respond to a variety of ligands. This paper highlights and summarises the most relevant recent findings pertinent to different classes of the RTK family of molecules, with a particular focus on elucidating their role in CNS axon regeneration. SN - 2090-1739 UR - https://doi.org/10.1155/2012/361721 DO - 10.1155/2012/361721 JF - Journal of Signal Transduction PB - Hindawi Publishing Corporation KW - ER -