The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications

Table 1

The Ras superfamily of small GTPases. The RasGTPase superfamily is divided into 9 families of small GTP-binding proteins on the basis of sequence and functional similarities (modified from [7]).

Ras	Rab	Rho	Sec	Arf	Rad	Ran	RheS	Rit
H-Ras	Rab1A	RhoA	N-Sec1	Arf1	Rad	Ran/TC4	Rhes	Rit
K-Ras	Rab1B	RhoB	S-Sec1	Arf2	Gem	Dexras1	Others	Rin
N-Ras	Rab2	RhoC	Sec4	Arf3	Kir	Others		Ric
E-Ras	Rab3A	RhoD	Sly1p	Arf4	Rem1			Others
TC21	Rab3B	RhoE	Others	Arf5	Rem2
R-Ras	Rab4	Rnd1		Arf6	Others
M-Ras	Rab5A	Rnd2		Arf7
Rap1A	Rab5B	RhoG		Others
Rap1B	Rab6	Rac1
Rap2A	Rab7	Rac2
Rap2B	Rab8	Rac3
RalA	Rab9	Cdc42
RalB	Rab10	TC10
Others	Others	TTF
		Others