Diverse Roles of JNK and MKK Pathways in the Brain

Table 2

Comparison of phenotypes of Mkk4 ^flox/flox  Nestin-Cre and Mkk7 ^flox/flox  Nestin-Cre mice.

Phenotype	Mkk4^flox/flox Nestin-Cre [37]	Mkk7^flox/flox Nestin-Cre [38]
Neuronal JNK activity	Suppressed	Suppressed
Age of lethality	Around 3 weeks old	At birth
Brain ventricle size at E18.5	Not reported	Enlarged
Striatum	Not reported	Reduced
Axon tracts (E18.5)	Unaffected	Greatly reduced
Axon tracts (postnatal)	Less fasciculated	Not determined
Intermediate filaments	Not reported	Accumulate in axons
Autophagic vacuoles	Not reported	Accumulate
JNK phosphorylation in axons	Not reported	Suppressed
L1-positive axons (E18.5)	Unaffected	Reduced
TAG-1-positive axons (E18.5)	Not reported	Reduced
Apoptosis	Unaffected	Unaffected
Cortical layer markers	Not reported	Expressed
Radial migration	Delayed	Delayed
Phosphorylation of c-Jun	Suppressed	Suppressed
Phosphorylation of NF-H	Suppressed	Suppressed
Phosphorylation of MAP1B	Suppressed	Suppressed
Phosphorylation of DCX	Unaffected	Suppressed