Research Article

Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

Figure 3

Changes in the duration of depolarization or hyperpolarization steps of the SQAP fail to enable upregulation of C a v 3.2 by ΔKelch. (a) Square AP with a shorter depolarization phase (0.5 ms, blue trace) or hyperpolarization phase (6 ms, orange trace). (b) Percentage of increase in calcium influx with the three protocols, with respect to control (action potential waveform, APW; the magnitude of the changes induced by the original APWs is shown with dotted lines ( 𝐾 = K L H L 1 ;   Δ 𝐾 = Δ K e l c h )); 𝑃 < 0 . 0 5 .
505346.fig.003a
(a)
505346.fig.003b
(b)