Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

Figure 4

Changes in the repolarization slope of the SQAP fail to enable upregulation of Ca_v3.2 by ΔKelch. (a) SQAP waveforms with instantaneous repolarization (black), midrange depolarization slope (70 mV/ms, blue), and slower repolarization (35 mV/ms, orange). (b) Percentage of increase in calcium influx with the three waveforms with respect to control; the extent of the changes induced by the original APWs is shown with dotted lines (𝐾=KLHL1;  Δ𝐾=ΔKelch); ^∗𝑃<0.05.

(a)

(b)