Research Article

Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

Figure 7

The APW-like stimulus produces an effect similar to an actual APW. (a) Stimulus (APW-like) created to replicate an actual APW (top) and APW-like stimuli with AHP slopes of 0.70 mV/ms and 0.35 mV/ms were compared. (b) Percentage of increase in calcium influx obtained with the stimuli shown above with respect to control; the magnitude of the changes induced by the original APWs is shown with dotted lines ( 𝐾 = K L H L 1 ;   Δ 𝐾 = Δ K e l c h ); 𝑃 < 0 . 0 5 .
505346.fig.007a
(a)
505346.fig.007b
(b)