Journal of Signal Transduction / 2012 / Article / Fig 2

Review Article

Angiogenic Signalling Pathways Altered in Gliomas: Selection Mechanisms for More Aggressive Neoplastic Subpopulations with Invasive Phenotype

Figure 2

Confocal microphotographs of the microvascular network during development of an ENU-induced glioma. Histochemistry for tomato lectin (LEA-FITC) performed on 40 μm sections. (a) Similar angioarchitecture to the normal brain during the early stage. (b) Tortuous and dilated vessels during the intermediate development stage. (c) The microvascular network is mainly composed of glomeruloid vessels in the periphery area, (d) Occasional huge dilated vessels in the intratumour region (bar scale of 20 μm).

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