Nucleic Acids in Human Glioma Treatment: Innovative Approaches and Recent Results

Table 2

MicroRNAs implicated in glioma.

miRNA		Function	Location	Targets	Cluster
Oncomir	miR-21	Inhibits apoptosis and promotes invasion	Chr 17 intergenic	TP53BP2 [44]; DAXX [44]; HNRNPK [44]; RECK [46]; TIMP3[46]; PDC4 [47]
	miR-221	Promotes proliferation and invasion	Chr X intergenic	PTPμ [48]; P27 [49]	miR-221/222
	miR-222	Promotes proliferation and invasion	Chr X intergenic	PTPμ [48]; P27 [49]	miR-221/222
	miR-9	Inhibits neural differentiation and induce proliferation	Chr 9; sense	CAMTA1 [50]; REST [52]
Tumor suppressor	miR-124	Induces G0/G1 cell cycle arrest; induce differentiation of adult mouse neural stem cells	Chr 8; sense	CDK6 [53]
	miR-137	Induces G0/G1 cell cycle arrest; induces differentiation of adult mouse neural stem cells	Chr 1; sense	CDK6 [53]	miR-137/2682
	miR-7	Tumor suppressor; suppresses EGFR expression and independently inhibits Akt pathway	Chr 9; sense	EGFR [55]
	miR-128	Inhibits cell proliferation by targeting Bmi-1 and E2F3a	Chr 2; sense	E2F3A; BMI1 [56]
	miR-181	Is downregulated and associated with poor prognosis	Chr 9; Sense antisense	unknown	miR-181a/b