Pathogenic Role of Store-Operated and Receptor-Operated Channels in Pulmonary Arterial Hypertension
Figure 2
Major causes for elevated PVR in patients with PAH. (a) Pulmonary angiogram from a healthy (normal) patient compared to a PAH patient, depicting the loss (occlusion) of pulmonary arteries. (b) Pulmonary EVG histology staining of cross-sections of a healthy patient compared to a PAH patient, depicting vascular remodeling and medial and intimal layer thickening. (c) Listed are the four major causes of elevated PVR in PAH patients [8].
