Table of Contents
Journal of Signal Transduction
Volume 2013, Article ID 239320, 12 pages
Research Article

An Fc Gamma Receptor-Mediated Upregulation of the Production of Interleukin 10 by Intravenous Immunoglobulin in Bone-Marrow-Derived Mouse Dendritic Cells Stimulated with Lipopolysaccharide In Vitro

Japan Blood Products Organization, Central Research Laboratory, Protein Pharmacology Research Section, 1-5-2 Minatojima Minami-machi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

Received 20 March 2013; Revised 24 May 2013; Accepted 2 June 2013

Academic Editor: Rudi Beyaert

Copyright © 2013 Akihiro Fujii et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

This Supplement data includes two experimental results (Figure S1 and Figure S2) which we mentioned in our report and one illustration (Figure S3) to help with the understanding of the readers about the mechanism studied in the report. Figure S1 shows effects of IVIG on the production of IL-10 and IL-12 p70 of BMDC stimulated with LPS for 6 h. Effects of IVIG on the mRNA transcription of IL-10 and IL-12 p70 of LPS-stimulated cells for 18 h were shown in Figure S2. Figure S3 illustrates the putative targets and mechanisms of IVIG on the cytokine production of BMDC.

  1. Supplementary Material