Table of Contents
Journal of Signal Transduction
Volume 2014, Article ID 173026, 6 pages
http://dx.doi.org/10.1155/2014/173026
Research Article

Signaling Network Map of Endothelial TEK Tyrosine Kinase

1Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore 560066, India
2School of Biotechnology, KIIT University, Bhubaneswar 751024, India
3Dr. M.G.R. Educational and Research Institute, Maduravoyal, Chennai 600095, India
4Manipal University, Madhav Nagar, Manipal 576104, India
5Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
6McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
7Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
8Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
9Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Received 22 April 2014; Accepted 15 September 2014; Published 13 October 2014

Academic Editor: Shoukat Dedhar

Copyright © 2014 Aafaque Ahmad Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

TEK tyrosine kinase is primarily expressed on endothelial cells and is most commonly referred to as TIE2. TIE2 is a receptor tyrosine kinase modulated by its ligands, angiopoietins, to regulate the development and remodeling of vascular system. It is also one of the critical pathways associated with tumor angiogenesis and familial venous malformations. Apart from the vascular system, TIE2 signaling is also associated with postnatal hematopoiesis. Despite the involvement of TIE2-angiopoietin system in several diseases, the downstream molecular events of TIE2-angiopoietin signaling are not reported in any pathway repository. Therefore, carrying out a detailed review of published literature, we have documented molecular signaling events mediated by TIE2 in response to angiopoietins and developed a network map of TIE2 signaling. The pathway information is freely available to the scientific community through NetPath, a manually curated resource of signaling pathways. We hope that this pathway resource will provide an in-depth view of TIE2-angiopoietin signaling and will lead to identification of potential therapeutic targets for TIE2-angiopoietin associated disorders.