Review Article

Signal Transduction in Astrocytes during Chronic or Acute Treatment with Drugs (SSRIs, Antibipolar Drugs, GABA-ergic Drugs, and Benzodiazepines) Ameliorating Mood Disorders

Figure 6

Effects on glycogenolysis (as percent of total glycogen) by 10 min acute exposure to 10 μM fluoxetine in cultured mouse astrocytes chronically treated (filled columns) with 10 μM fluoxetine for either 1 week (a) or for 2-3 weeks (b), compared to the effect of acute fluoxetine administration to similar untreated cultures from the same batches measured in the same experiments (open cloumns). In both (a) and (b) the treatment effect is significant ( or better). Glycogenolytic rates in (a) and (b) for the treated cultures were different at , whereas there was no significant difference in the untreated cultures, from Kong et al. [8].
593934.fig.006a
(a)
593934.fig.006b
(b)