Review Article

A Network Map of FGF-1/FGFR Signaling System

Table 2

Functions of FGF-1 identified in diverse cell/tissue types of human and other mammalian origins.

FunctionPubMed IDCell type/tissueOrganism

Adipogenesis22187378, 17068114PreadipocytesHuman
Apoptosis20657013Hepatoma cells, HEK293 cellsHuman
15773903Motor neuronRat
9681989Peroxynitrite-induced apoptosis in PC12 cellsRat
Cell cycle arrest16153144cellsHuman
Cell migration9108375Skin fibroblastsHuman
11019781FibroblastsMouse
Cell proliferation9182757Embryo fibroblastsRat
2441696Arterial smooth muscle cellsHuman
14966081AT2 alveolar cellsHuman
15094393Human long-bone growth plate chondrocytesHuman
1699952Umbilical vein endothelial ceilsHuman
15767480Y79 cellsHuman
2303528Epidermal keratinocytes (BALB-MK1)Mouse
2303528Keratinocytes (BALB/MK-1)Mouse
2383402Leydig cells (TM3)Mouse
1379845Megakaryocyte progenitor cellsMouse
1379845MegakaryocytesMouse
14985304Murine lens epithelial cell lines CRLE2, 1AMLE6, TN4-1 and NKR11Mouse
15574884NIH-3T3 cellsMouse
3272188Adrenal chromaffin cellsRat
2566605AstroblastsRat
1377078Hippocampal astrocytesRat
2153969Rat bladder carcinoma cell line (NBT-II)Rat
8622701PC12 cellsRat
8732667Prostate cancer cellsRat
1638984Retinal cellsRat
1377078Skin fibroblastsRat
12907464Aortic smooth muscle cellsHuman, rat
1638984Retinal cellsRats
22108586Periodontal fibroblastsRat
3272188Adrenal chromaffin cellsRat
22108586Periodontal ligament fibroblastsRat
20388777SUM-52PE cellsHuman
Cell rounding, growth inhibition11779141ATDC5 cells, chondroprogenitor cell linesMouse
Cholesterol biosynthesis19713443Mouse fibroblasts and rat astrocytesMouse, rat
19229075AstrocytesRat
18216067AstrocytesRat
17548887AstrocytesRat
Differentiation20497026Embryonic stem cell (mESC) line E14-Tg2aMouse
Epithelial-mesenchymal transition2153969NBT-II cells (Rat bladder carcinoma cell line)Rat
7593195NBT-IIRat
2153969NBT-IIRat
Fiber cell differentiation7539358Lens epithelial cellsMouse
G0/G1 arrest21051949Chondrosarcoma cellsRat
G2 arrest21051949Chondrosarcoma cellsRat
G2/M transition20044603Breast cancer cellsHuman
Growth arrest14593093Rat chondrosarcoma (RCS) cellsRat
Inhibition of apoptosis16524372AstrocytesRat
17473910, 16091747PC12 and RetsAF cellsRat
Inhibition of cell growth17363592TAKA-1 cellsHamster
Inhibition of neurogenesis11466430NEP cellsMouse
Inhibition of proliferation10364154Chondrosarcoma cells (RCS)Rat
Membrane ruffling7534069Human ductal breast epithelial tumor cell line (T47D)Human
Neurite outgrowth20175207TREX 293 cellsHuman
3272188Adrenal chromaffin cellsRat
8764646PC12 cellsRat
19249349PC12 cellsRat
3316527, 8576258PC12 cellsRat
12127979, 9182757, 2157719PC12 cellsRat
Neuronal differentiation16716298Primary astrocyte from human fetal brainHuman
7514169, 8622701, 2157719PC12 cellsRat
Osteoblast proliferation18041768ENU1564 cellsRat
Osteoblast differentiation18505824OsteoblastsMouse
Osteogenic differentiation12674336Sutural mesenchyme in mouse calvariaMouse
Protection from apoptosis19765618, 8576258PC12 cellsRat
Repression of myogenic differentiation1379245Skeletal muscle myoblasts (MM14)Mouse
Retinal cell proliferation15978261Retinal cellsMouse
Skeletal muscle development8601591Skeletal muscle myoblasts (MM14)Mouse
Synaptic plasticity20649566Hippocampal neuronal cell line HT22Mouse
Tumorigenesis20889570JMSU1 urothelial carcinoma cell linesHuman
9038374NBD-IIRat
Vascular remodeling15121739Pulmonary arterial smooth muscle cells (PASMCs)Rat
22205500ASM (Airway Smooth Muscle cells)Human
Regeneration3353388Retinal ganglion cellsRat
Astrocyte activation15773903Primary spinal cord astrocyteRat
Neurogenesis20429889Embryonic stem cellsMouse
Wound healing9036931Mouse
Cord Formation16631103Rat
Decrease in food intake7692459Rat
Facilitation of memory7692459Rat
Increase in sleep duration8985960Rabbit
Maintenance of the integrity of the organ of corti, initiation of protective recovery and repair processes following damaging auditory stimuli7568115Rat
Arteriole dilation8853345Rat
Feeding suppressor function11172932Rat
Hair-cell innervation during the terminal development of the sensory epithelium12792312Rat
Lens regeneration3792708Bovine
Lung morphogenesis and differentiation12242715Rat
Metastasis1707175Rat
Muscle regeneration1384586Mouse
Myocardial remodeling19629561Rat
Neuroprotection12095987Rat
Prevention of premature angiogenesis and inflammatory responses17643421Mouse
Protection against hypoxic-ischemic injury16635575Rat
Spinal cord injury repair21411654Rat
Cardioprotection15337227, 12176126Mouse