TGF-β Signaling Cooperates with AT Motif-Binding Factor-1 for Repression of the α-Fetoprotein Promoter
Figure 6
ATBF1N and ATBF1C perturb ATBF1-mediated suppression of the activity of the AFP promoter upon TGF-β stimulation. ATBF1N (a) and ATNF1C (b) rescue ATBF1-mediated repression of the activity of the AFP promoter. HepG2 cells were transfected with increased amounts of either ATBF1N (50, 100, or 200 ng) (a) or ATBF1C (50, 100, or 200 ng) (b) together with ATBF1 (200 ng) and Δ2.7Luc (200 ng). The cells were then stimulated with 5 ng/mL TGF-β.
