Table of Contents
Journal of Signal Transduction
Volume 2016, Article ID 1362407, 8 pages
Review Article

Thyroid Hormones as Renal Cell Cancer Regulators

1Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
2Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland
3Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland
4School of Molecular Medicine, Medical University of Warsaw, Zwirki i Wigury 61, 02-091 Warsaw, Poland
5Institute of Biochemistry and Biophysics, Pawinskiego 5a, 02-106 Warsaw, Poland

Received 28 October 2015; Accepted 23 February 2016

Academic Editor: Leonidas C. Platanias

Copyright © 2016 Łukasz Szymański et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It is known that thyroid hormone is an important regulator of cancer development and metastasis. What is more, changes across the genome, as well as alternative splicing, may affect the activity of the thyroid hormone receptors. Mechanism of action of the thyroid hormone is different in every cancer; therefore in this review thyroid hormone and its receptor are presented as a regulator of renal cell carcinoma.