Table of Contents
Journal of Sexually Transmitted Diseases
Volume 2017, Article ID 2857397, 6 pages
Research Article

Discordant HIV Test Results: Implications on Perinatal and Haemotransfusion Screening for HIV Infection, Cape Coast, Ghana

1Laboratory Department, Metropolitan Hospital, P.O. Box 174, Cape Coast, Ghana
2Department of Community Medicine and Health, Anglican University College of Technology, P.O. Box 74, Nkoranza, Ghana

Correspondence should be addressed to Ato Kwamena Tetteh; moc.kooltuo@hettetka

Received 5 July 2017; Accepted 29 August 2017; Published 8 October 2017

Academic Editor: Hsin-Yun Sun

Copyright © 2017 Ato Kwamena Tetteh and Edward Agyarko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Screening results of 488 pregnant women aged 15–44 years whose blood samples had been tested on-site, using First Response® HIV 1/2, and confirmed with INNO-LIA™ HIV I/II Score were used. Of this total, 178 were reactive (HIV I, 154; HIV II, 2; and HIV I and HIV II, 22). Of the 154 HIV I-reactive samples, 104 were confirmed to be HIV I-positive and 2 were confirmed to be HIV II-positive, while 48 were confirmed to be negative [false positive rate = 17.44% (13.56–21.32)]. The two HIV II samples submitted were confirmed to be negative with the confirmatory test. For the 22 HIV I and HIV II samples, 7 were confirmed to be HIV I-positive and 1 was confirmed to be HIV I- and HIV II-positive, while 14 were confirmed to be negative. Of the 310 nonreactive samples, 6 were confirmed to be HIV I-positive and 1 was confirmed to be HIV II-positive [false negative rate = 5.79% (1.63–8.38)], while 303 were negative. False negative outcomes will remain unconfirmed, with no management options for the client. False negative rate of 5.79% requires attention, as its resultant implications on control of HIV/AIDS could be dire.