Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient

Table 4

Organ weight changes in male and female breeding Sprague-Dawley rats in the F₀ and F₁ generations of the two-generation rat study.

Generation	F0				F1
Dose (mg/kg/day) (𝑛)	0 (𝑛=26)	200 (𝑛=26)	1000 (𝑛=26)	2000 (𝑛=26)	0 (𝑛=22)	200 (𝑛=22)	1000 (𝑛=20)	2000 (𝑛=26)
Male
Thyroids, absolute organ weight (mg)^A	30.01±5.45^C	31.65±5.94	29.94±3.88	30.32±3.95	30.19±4.48	31.89±4.91	35.15±5.27^∗∗	32.09±4.18
Thyroids, relative organ weight (mg)^B	5.23±0.68	5.33±0.86	5.33±0.73	5.34±0.78	4.55±0.61	4.76±0.73	5.48±0.90^∗∗	4.94±0.58
Adrenals, absolute organ weight (mg)	61.81±7.05	63.95±10.16	59.48±7.40	68.90±9.01^∗∗	62.18±7.30	63.96±5.83	57.61±7.52	62.28±9.25
Adrenals, relative organ weight (mg)	10.88±1.31	10.82±1.68	10.57±1.28	12.10±1.58^∗∗	9.41±1.14	9.56±1.07	8.95±1.08	9.62±1.57
Seminal Vesicles, absolute organ weight (g)	3.11±0.33	2.90±0.37	3.12±0.37	3.05±0.34	3.40±0.29	3.26±0.44	3.23±0.39	3.13±0.37
Seminal vesicles, relative organ weight (g)	0.55±0.07	0.49±0.09^∗	0.55±0.08	0.54±0.06	0.52±0.08	0.49±0.01	0.51±0.08	0.48±0.06
Generation	F0				F1
Dose (mg/kg/day) (𝑛)	0 (𝑛=26)	200 (𝑛=26)	1000 (𝑛=26)	2000 (𝑛=26)	0 (𝑛=18)	200 (𝑛=17)	1000 (𝑛=18)	2000 (𝑛=19)
Female
Liver, absolute organ weight (g)	13.70±1.30	13.99±1.08	14.39±1.62	14.48±1.11	15.01±1.28	15.45±1.86	16.02±1.46	15.71±1.35
Liver, relative organ weight (g)	3.86±0.32	4.05±0.31	4.17±0.35^∗∗	4.23±0.29^∗∗	4.12±0.34	4.17±0.41	4.36±0.33	4.42±0.33^∗

Significantly different from control: ^∗𝑃<.05, ^∗∗𝑃<.01; ^Aabsolute organ weight is the weight of the organ; ^Brelative organ weight is the weight of the organ relative to the body weight at necropsy (body weight ratio); ^Cmean ± standard deviation; 𝑛: number of male and female rats per dose group.