Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient

Table 6

Effect of SE5-OH administration on the F₁ generation rat dam reproductive performance.

Dose (mg/kg/day)	Mean estrus cycle	Incidence of irregular estrus cycle	Mating period		Copulation index (%)^A	Fertility index (%)^B
			Number of estrus	Day of conceiving
0	4.36±0.46#		0.1±0.6	3.1±2.8	95.5	85.7
	(𝑛=24)	0/24	(𝑛=22)	(𝑛=21)	(21/22)	(18/21)
200	4.31±0.45		0.2±0.7	2.8±1.8	95.7	86.4
	(𝑛=21)	2/23	(𝑛=23)	(𝑛=22)	(22/23)	(19/22)
1000	4.39±0.41		0.1±0.2	2.3±1.3	100.0	95.0
	(𝑛=20)	0/20	(𝑛=20)	(𝑛=20)	(20/20)	(19/20)
2000	4.30±0.43		0.0±0.0	2.5±1.5	100.0	95.5
	(𝑛=21)	1/22	(𝑛=22)	(𝑛=22)	(22/22)	(21/22)

#Mean ± standard deviation; ^Anumber of copulated females/number of pairs; ^Bnumber of pregnant females/number of copulated females; 𝑛: number of mating pairs.