Journal of Toxicology / 2009 / Article / Tab 1

Research Article

Molecular and Biochemical Effects of a Kola Nut Extract on Androgen Receptor-Mediated Pathways

Table 1

Regulation of androgen receptor target genes by Biz-2.

GenesmRNA expression relative to controlGene description
10 ppm–24 h10 nM–24 h10 nM–24 h
Fold SEM N Fold SEM N Fold SEM N

PSA10.552.2638.090.9133.660.183Prostate-specific antigen: prostate tumor marker
NKX3-13.9320.74313.842.2132.510.243NK3 homeobox: a novel human prostate-specific, androgen-regulated homeobox gene associated with prostate cancer progression
TSC225.951.4431.380.1632.450.253Tuberous sclerosis 22: a leucine zipper transcription factor whose expression is induced by TGF-b
PART-110.30.350.02Prostate androgen-regulated transcript 1: androgen-inducible gene that is regulated by androgens and phytoestrogen
ER 1.170.431.080.3231.270.213Estrogen receptor : nuclear transcription factor that mediates transcription of nonsteroidal and steroidal ligands
ER 1.360.28131.360.28131.480.353Estrogen receptor : ligand-inducible nuclear transcription factor that mediates estrogen-dependent gene expression in females
AR2.840.2031.2710.1130.440.013Androgen receptor: transcription factor that mediates transcription of genes required for development of male reproductive tissues
Bcl22.682.6830.850.0731.140.123B cell leukemia/lymphoma-2: an antiapoptotic protein known to regulate apoptotic pathway and protect against cell death
Bax9.972.1337.640.0933.450.173Bcl2-associated X-protein: a proapoptotic protein that regulates apoptotic pathway and promotes cell death