Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis
Figure 5
Effect of antioxidants and an antioxidant enzyme on protein
expression of beclin-1. Cells were pretreated for 2 hours with either catalase,
HBED, MnTBAP, or CuDIPS, followed by a 24-hour incubation with 0.2 mM DOC.
(a) All pretreatments decreased both the constitutive beclin-1 protein levels and
the DOC-induced increase in beclin-1 protein levels, with catalase being the most
effective. (b) The Brilliant Blue loading control with the position of the beclin-1
band indicated by the arrow.
