Review Article
Liposomal Antioxidants for Protection against Oxidant-Induced Damage
Table 1
Antioxidants delivered as liposomal formulations in animal models of oxidative stress.
| Antioxidant | Route of administration | Experimental model | Target organ | Reference(s) |
| | iv | Acetaminophen poisoning (rat) | Liver | [49] | | iv (PEG-Liposome) | Rheumatoid arthritis (rat) | Paws | [50] | SOD | im | Radiation-induced injury (human) | Skin and underlying tissues | [51, 52] | | iv | Cold-induced brain injury (rat) | Brain | [53] | | iv | Cerebral ischemia-carotid artery occlusion | Brain | [54, 55] | | subgingivally | Peridontitis (dogs) | Gingiva | [56] |
| | iv | Hyperoxia | Lung | [57, 58] | | it | Oxidative stress-induced injury (Xanthine/xanthine oxidase ) (rabbit) | Lung | [59] | SOD and/or CAT | it | Hyperoxia (rat) | Lung | [60] | | it | Hyperoxia (premature rabbit) | Lung | [61] | | it | Bleomycin-induced injury (rat) | Lung | [62, 63] | | It (PEG-Liposome) | 2-chloroethyl ethyl sulfide (CEES) (rat) | Lung | [64] |
| CAT | it | Hyperoxia (rat) | Lung | [65] |
| | oral | Atherosclerosis (mice) | Aortic arch | [66] | | iv | Paracetamol poisoning (mice) | Liver | [67] | GSH | it | Human-premature infants | Lung | [68] | | | Parkinson’s disease | In vitro neuronal/glial cell cultures | [69] | | it | 2-chloroethyl ethyl sulfide (CEES) (rat) | Lung | [64, 70] |
| GSH/α-tocopherol | it | Paraquat poisoning | Lung | [71] |
| | it | Shock (rat) | Lung | [72] | NAC | iv | Acetaminophen poisoning (mice) | Liver | [73] | | it | 2-chloroethyl ethyl sulfide (CEES) (rats) | Lung | [70] |
| | iv | LPS-induced injury (rat) | Lung | [74] | | iv | LPS-induced injury(rat) | Liver | [75] | α-tocopherol | it | Bleomycin (rat) | Lung | [76] | | it | Paraquat poisoning | Lung | [77] | | it | Phorbol-myristate acetate (rat) | Lung | [78] | | ip | Melphalan toxicity (mice) | Lung | [79] |
| α-tocopherol/L-ascorbic acid | iv | Partial cerebral ischemia (rat) | Brain | [80] |
| α,γ,δ-tocopherols/NAC | it | 2-chloroethyl ethyl sulfide (CEES) (guinea pigs) | Lung | [81] |
| Quercetin | intraventricular | Myocardial injury (rats) peroxynitrite-induced myocardial injury in isolated hearts and animals | Heart | [82] | iv | Arsenite poisoning (rats) | Liver | [83] |
| CoQ10 | topical | Photoaging | Skin | [84] |
| Curcumin | oral | Bioavailability study | Plasma | [85] |
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Iv: intravenous, It: intratracheal, Ip: intraperitoneal, Im: intramuscular, and PEG: polyethylene glycol.
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