Journal of Toxicology / 2011 / Article / Tab 1

Review Article

Liposomal Antioxidants for Protection against Oxidant-Induced Damage

Table 1

Antioxidants delivered as liposomal formulations in animal models of oxidative stress.

AntioxidantRoute of administrationExperimental modelTarget organReference(s)

ivAcetaminophen poisoning (rat)Liver[49]
iv (PEG-Liposome)Rheumatoid arthritis (rat)Paws[50]
SODimRadiation-induced injury (human)Skin and underlying tissues[51, 52]
ivCold-induced brain injury (rat)Brain[53]
ivCerebral ischemia-carotid artery occlusionBrain[54, 55]
subgingivallyPeridontitis (dogs)Gingiva[56]

ivHyperoxiaLung[57, 58]
itOxidative stress-induced injury (Xanthine/xanthine oxidase ) (rabbit)Lung[59]
SOD and/or CATitHyperoxia (rat)Lung[60]
itHyperoxia (premature rabbit)Lung[61]
itBleomycin-induced injury (rat)Lung[62, 63]
It (PEG-Liposome)2-chloroethyl ethyl sulfide (CEES) (rat)Lung[64]

CATitHyperoxia (rat)Lung[65]

oralAtherosclerosis (mice)Aortic arch[66]
ivParacetamol poisoning (mice)Liver[67]
GSHitHuman-premature infantsLung[68]
Parkinson’s diseaseIn vitro neuronal/glial cell cultures[69]
it2-chloroethyl ethyl sulfide (CEES) (rat)Lung[64, 70]

GSH/α-tocopherolitParaquat poisoningLung[71]

itShock (rat)Lung[72]
NACivAcetaminophen poisoning (mice)Liver[73]
it2-chloroethyl ethyl sulfide (CEES) (rats)Lung[70]

ivLPS-induced injury (rat)Lung[74]
ivLPS-induced injury(rat)Liver[75]
α-tocopherolitBleomycin (rat)Lung[76]
itParaquat poisoningLung[77]
itPhorbol-myristate acetate (rat)Lung[78]
ipMelphalan toxicity (mice)Lung[79]

α-tocopherol/L-ascorbic acidivPartial cerebral ischemia (rat)Brain[80]

α,γ,δ-tocopherols/NACit2-chloroethyl ethyl sulfide (CEES) (guinea pigs)Lung[81]

QuercetinintraventricularMyocardial injury (rats) peroxynitrite-induced myocardial injury in isolated hearts and animalsHeart[82]
ivArsenite poisoning (rats)Liver[83]

CoQ10topicalPhotoagingSkin[84]

CurcuminoralBioavailability studyPlasma[85]

Iv: intravenous, It: intratracheal, Ip: intraperitoneal, Im: intramuscular, and PEG: polyethylene glycol.