Liposomal Antioxidants for Protection against Oxidant-Induced Damage

Table 1

Antioxidants delivered as liposomal formulations in animal models of oxidative stress.

Antioxidant	Route of administration	Experimental model	Target organ	Reference(s)
	iv	Acetaminophen poisoning (rat)	Liver	[49]
	iv (PEG-Liposome)	Rheumatoid arthritis (rat)	Paws	[50]
SOD	im	Radiation-induced injury (human)	Skin and underlying tissues	[51, 52]
	iv	Cold-induced brain injury (rat)	Brain	[53]
	iv	Cerebral ischemia-carotid artery occlusion	Brain	[54, 55]
	subgingivally	Peridontitis (dogs)	Gingiva	[56]
	iv	Hyperoxia	Lung	[57, 58]
	it	Oxidative stress-induced injury (Xanthine/xanthine oxidase ) (rabbit)	Lung	[59]
SOD and/or CAT	it	Hyperoxia (rat)	Lung	[60]
	it	Hyperoxia (premature rabbit)	Lung	[61]
	it	Bleomycin-induced injury (rat)	Lung	[62, 63]
	It (PEG-Liposome)	2-chloroethyl ethyl sulfide (CEES) (rat)	Lung	[64]
CAT	it	Hyperoxia (rat)	Lung	[65]
	oral	Atherosclerosis (mice)	Aortic arch	[66]
	iv	Paracetamol poisoning (mice)	Liver	[67]
GSH	it	Human-premature infants	Lung	[68]
		Parkinson’s disease	In vitro neuronal/glial cell cultures	[69]
	it	2-chloroethyl ethyl sulfide (CEES) (rat)	Lung	[64, 70]
GSH/α-tocopherol	it	Paraquat poisoning	Lung	[71]
	it	Shock (rat)	Lung	[72]
NAC	iv	Acetaminophen poisoning (mice)	Liver	[73]
	it	2-chloroethyl ethyl sulfide (CEES) (rats)	Lung	[70]
	iv	LPS-induced injury (rat)	Lung	[74]
	iv	LPS-induced injury(rat)	Liver	[75]
α-tocopherol	it	Bleomycin (rat)	Lung	[76]
	it	Paraquat poisoning	Lung	[77]
	it	Phorbol-myristate acetate (rat)	Lung	[78]
	ip	Melphalan toxicity (mice)	Lung	[79]
α-tocopherol/L-ascorbic acid	iv	Partial cerebral ischemia (rat)	Brain	[80]
α,γ,δ-tocopherols/NAC	it	2-chloroethyl ethyl sulfide (CEES) (guinea pigs)	Lung	[81]
Quercetin	intraventricular	Myocardial injury (rats) peroxynitrite-induced myocardial injury in isolated hearts and animals	Heart	[82]
	iv	Arsenite poisoning (rats)	Liver	[83]
CoQ10	topical	Photoaging	Skin	[84]
Curcumin	oral	Bioavailability study	Plasma	[85]

Iv: intravenous, It: intratracheal, Ip: intraperitoneal, Im: intramuscular, and PEG: polyethylene glycol.