The Loss of HIF1𝜶 Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts

Figure 6

Cellular glutathione levels under CdCl₂ treatment. Total cellular glutathione levels (a) and reduced glutathione levels (b) in wild-type (WT, white bars) and HIF1α  −/− (black bars) cells were determined. Cells were left untreated (Ctrl), or treated with 5 μM CdCl₂ (Cd²⁺) for 24 hours. *𝑃<0.05 compared to respective controls, 𝑛=4. ^#𝑃<0.05, significant compared to wild-type cells, 𝑛=4.

(a)

(b)