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Journal of Toxicology
Volume 2011, Article ID 430539, 7 pages
Research Article

Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats

1División de Ciencias Naturales y Exactas, Departamento de Farmacia, Universidad de Guanajuato, Noria Alta s/n, 36050 Guanajuato, Gto., Mexico
2Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Gonzalitos 235 Norte, Col Mitras Centro, 64460 Monterrey Nuevo León, Mexico
3Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey Nuevo León, Mexico
4División de Ciencias de la Salud, Departamento de Medicina y Nutrición, Universidad de Guanajuato, 20 de Enero 929, 37320 León, Gto., Mexico

Received 8 March 2011; Accepted 26 May 2011

Academic Editor: Jack Ng

Copyright © 2011 Yolanda Alcaraz-Contreras et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The effectiveness of glycine in treating experimental lead intoxication was examined in rats. Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycine (100 and 500 mg/kg, orally) once daily for 5 days or glycine (1000 mg/kg, orally) once daily for 28 days. The effect of these treatments on parameters indicative of oxidative stress (glutathione and malondialdehyde levels), the activity of blood 𝛿 -aminolevulinic acid dehydratase, and lead concentration in blood, liver, kidney, brain, and bone were investigated. Liver samples were observed for histopathological changes. Glycine was found to be effective in (1) increasing glutathione levels; (2) reducing malondialdehyde levels; (3) decreasing lead levels in bone with the highest dose. However, glycine had no effect on lead mobilization when 100 and 500 mg/kg glycine were administered. In microscopic examination, glycine showed a protective effect against lead intoxication.