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Journal of Toxicology
Volume 2011, Article ID 628151, 6 pages
http://dx.doi.org/10.1155/2011/628151
Research Article

Blood Harmane Concentrations in 497 Individuals Relative to Coffee, Cigarettes, and Food Consumption on the Morning of Testing

1GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032-2699, USA
2Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10027-6900, USA
3Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032-3727, USA
4Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
5School of Health Sciences, Purdue University, West Lafayette, IN 47907-2051, USA

Received 23 November 2010; Revised 11 February 2011; Accepted 16 February 2011

Academic Editor: Margaret James

Copyright © 2011 Elan D. Louis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Harmane, a potent neurotoxin linked with several neurological disorders, is present in many foods, coffee, and cigarettes. We assessed whether morning food/coffee consumption and smoking were reflected in blood harmane concentrations (BHCs) we obtained in an epidemiologic sample ( 𝑛 = 4 9 7 ). Participants who smoked on the morning of phlebotomy had similar logBHCs to those who had not smoked ( 𝑃 = . 5 7 ); there was no correlation between logBHCs and number of cigarettes ( 𝑃 = . 5 9 ). Among the coffee drinkers, there was no correlation between number of cups and logBHCs ( 𝑃 = . 9 8 ). Participants who had eaten on the morning of phlebotomy had similar logBHCs to those who had not ( 𝑃 = . 4 9 ); logBHCs did not correlate with the time latency between last food consumption and phlebotomy ( 𝑃 = . 7 4 ). BHCs in this sample of ~500 individuals did not covary with recent smoking, coffee, or food consumption, suggesting that our inability to withhold these exposures on the morning of phlebotomy was not reflected in the BHCs we measured.