Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis

Table 1

Baseline characteristics and exposure to treatment.

	Celecoxib; 400 mg b.i.d.; (N = 396)	Ibuprofen; 800 mg t.d.s.; (N = 396)
Exposure to treatment median (days)	182	176
Age
Mean (years)	55.2	54.9
60–70 years (%)	26.6	25.5
≥70 years (%)	5.2	3.9
Female	68.5	70.8
History (%)
Hypertension	39.0	38.1
Diabetes	8.8	8.1
Creatinine
Serum level (mg/dL)	0.79	0.77
Clearance (mL/min.)*	112.2	116.4

b.i.d. twice a day; t.d.s. three times a day.
*estimated by Cockroft-Gault formula.