Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis

Table 3

Fluid retention effects of celecoxib versus ibuprofen.

	Celecoxib; 400 mg b.i.d.; (N = 396)	Ibuprofen; 800 mg t.d.s.; (N = 396)
Any edema-related adverse events (% of patients)^§	4.1	6.2*
CHF Congestive Heart Failure (% of patients)	0.5	0.5
Withdrawals for edema-related adverse events (% of patients)	0.7	1.0
Withdrawals due to CHF (% of patients)	0.1	0.3
Increase in body weight of ≥3% (% of patients)	20.7	21.1

b.i.d. twice a day; t.d.s. three times a day.
^§Includes investigator reports of edema, generalized edema or peripheral edema.
* 𝑃<.05 versus celecoxib by Fisher exact test.