Research Article

Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis

Table 4

Renal effects of celecoxib versus ibuprofen.

Celecoxib
400 mg b.i.d.
(N = 396)
Ibuprofen
800 mg t.d.s.
(N = 396)

Mean change in serum creatinine (mg/dL)0.009 ± 0.0020.027 ± 0.004*
Mean change in estimated creatinine clearance (ml/min)0.08 ± 0.37−2.82 ± 0.51*

b.i.d. twice a day; t.d.s. three times a day.
* versus celecoxib by Fisher exact test.