Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis

Table 5

Renal functions in patients with prerenal azotemia at baseline (BUN > 20 mg/dL).

Comparison item	Celecoxib; 400 mg b.i.d.; (N = 126); Of total 396	Ibuprofen; 800 mg t.d.s; (N = 146); Of total 396
Baseline serum creatinine (mg/dL)	0.93	0.94
Estimated baseline creatinine clearance (mg/dL)	91.1	91.3
Mean change in serum creatinine (mg/dL)	0.003 ± 0.007	0.049 ± 0.012*
Mean change in estimated creatinine clearance (ml/min.)	1.27 ± 0.69	−1.65 ± 1.03*
Withdrawal of study owing to adverse event	1.5	4.2*

b.i.d. twice a day; t.d.s. three times a day; BUN: blood urea nitrogen.
^∗𝑃<.05 by analysis covariance by Fisher exact test.