Reconstructing Organophosphorus Pesticide Doses Using the Reversed Dosimetry Approach in a Simple Physiologically-Based Pharmacokinetic Model

Table 1

Descriptive statistics for the estimated daily dose (𝜇g/kg/day) of chlorpyrifos in thirteen children ages 2–5 using the simple pharmacokinetic model.

Overall	SPK I	SPK II	SPK III
Mean (St. Dev.)	0.98 (1.95)	0.97 (1.19)	0.87 (0.81)
Median	0.37	0.82	0.92
N	21	23	26
95% confidence interval (lower, upper)	(0.09, 1.86)	(0.43, 1.51)	(0.51, 1.24)
Min–max	(0, 9.13)	(0, 5.5)	(0, 3.65)
Summer season
Mean (St. Dev.)	0.55 (0.58)	0.8 (1.0)	0.73 (0.68)
Median	0.34	0.27	0.52
N	10	11	13
95% confidence interval (lower, upper)	(0.19, 0.91)	(0.24, 1.37)	(0.37, 1.09)
Min–max	(0, 1.89)	(0, 3.36)	(0, 2.5)
Fall season
Mean (St. Dev.)	1.3 (2.53)	1.32 (1.42)	1.13 (0.9)
Median	0.42	0.97	0.94
N	11	12	13
95% confidence interval (lower, upper)	(0, 2.67)	(0.55, 2.09)	(0.66, 1.6)
Min–max	(0.05, 9.13)	(0.2, 5.5)	(0.23, 3.65)
Urban/suburban children
Mean (St. Dev.)	0.48 (0.52)	0.67 (0.64)	0.63 (0.55)^1
Median	0.35	0.48	0.45
N	11	12	12
95% confidence interval (lower, upper)	(0.19, 0.77)	(0.31, 1.03)	(0.32, 0.94)
Min–max	(0.04, 1.88)	(0.02, 2.27)	(0.01, 1.97)
Agricultural children
Mean (St. Dev.)	1.53 (2.73)	1.51 (1.58)	1.19 (0.92)^1
Median	0.88	1.06	1.04
N	10	11	14
95% confidence interval (lower, upper)	(0.1, 2.96)	(0.91, 2.11)	(0.68, 1.7)
Min–max	(0, 9.12)	(0, 5.5)	(0, 3.65)

1 Marginally significantly different (one-way ANOVA, 𝑃=0.077).