Reconstructing Organophosphorus Pesticide Doses Using the Reversed Dosimetry Approach in a Simple Physiologically-Based Pharmacokinetic Model
Table 2
The dose estimates (g/kg/day) for chlorpyrifos using PBPK, SPK I, SPK II and SPK III model simulations.
Subject ID1
Season
Body wt. (kg)
PBPK
SPK I2
SPK II3
SPK III4
R1
Summer
15.5
0.004
0.546
0.273
1.140
R2
Summer
21.4
0.003
0.281
0.246
0.380
R3
Summer
14.5
0.004
0.043
0.022
0.014
R4
Summer
16.8
0.003
0.831
1.439
0.987
R5
Summer
13.4
0.004
0.338
0.213
0.158
R6
Summer
19.6
0.003
n.a. 5
0.840
0.520
S1
Summer
17.3
0.003
0
0
0
S2
Summer
18.2
0
0.224
0.112
0.488
S3
Summer
15
0
n.a. 5
3.357
2.497
S4
Summer
15.5
0
1.881
1.450
1.282
S5
Summer
16.8
0.004
n.a. 5
n.a. 5
0.326
S6
Summer
22.7
0.440
0.808
0.820
0.672
S7
Summer
14.5
0
n.a. 5
n.a. 5
1.056
R1
Fall
15.5
0.004
1.881
2.274
1.973
R2
Fall
21.4
0.003
0.051
0.204
0.229
R3
Fall
14.5
0.012
0.347
0.980
0.944
R4
Fall
16.8
0.003
0.366
0.541
0.603
R5
Fall
13.4
0.018
0.082
0.483
0.368
R6
Fall
19.6
0.005
0.476
0.476
0.250
S1
Fall
17.3
2.302
9.125
5.496
3.647
S2
Fall
18.2
0.003
0.172
0.949
1.110
S3
Fall
15
0.004
1.060
1.060
1.219
S4
Fall
15.5
0
0.956
1.260
1.017
S5
Fall
16.8
0
1.028
1.184
0.922
S6
Fall
22.7
0.001
0.041
0.969
0.934
S7
Fall
14.5
0.006
n.a. 5
n.a. 5
1.513
“R” for children living in agricultural community and “S” for children living in urban/suburban community. Significantly different to PBPK dose estimates (paired t-test, ). Significantly different to PBPK dose estimates (paired t-test,). Significantly different to PBPK dose estimates (paired t-test, ). Missing data due to missing spot urine samples.
