Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans

<table>Evaluation of the confidence in applying the QPPR for <svg height="14.4375" id="M138" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 46.625 14.4375" width="46.625" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝐶</tspan>
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<tspan style="font-size: 8.75px; " x="0" y="0">i</tspan>
<tspan style="font-size: 8.75px; " x="2.4330561" y="0">n</tspan>
<tspan style="font-size: 8.75px; " x="6.8090558" y="0">t</tspan>
<tspan style="font-size: 8.75px; " x="9.2421122" y="0">P</tspan>
<tspan style="font-size: 8.75px; " x="14.116976" y="0">L</tspan>
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Journal of Toxicology

fig1

Figure 1

Figure 1: Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans 

Figure 1 | Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans 