Quantitative Property-Property Relationship for Screening-Level Prediction of Intrinsic Clearance of Volatile Organic Chemicals in Rats and Its Integration within PBPK Models to Predict Inhalation Pharmacokinetics in Humans

Figure 6

24 h simulation of the venous blood concentration following inhalation exposure to 1 ppm, 8 h for 11 volatile organic compounds considering maximum and minimum (bold lines) and QPPR-based hepatic extraction (grey area). (a) 1,1,1-Trichloroethane; (b) 1,2,4-trimethylbenzene; (c) 1,2-dichloroethylene (trans-); (d) bromoform; (e) dibromochloromethane; (f) ethylene; (g) furan; (h) halothane; (i) o-xylene; (j) propylene; (k) tetrachloroethylene.

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