Journal of Toxicology / 2012 / Article / Tab 3

Research Article

Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration

Table 3

Regression coefficient for blood cadmium by GSTP1  Val105Ile and interaction between GSTP1  Val105Ile and GSTT1 and GSTM1.

GenotypeBlood cadmium
n 𝛽 ( S . E . ) a 𝑃 valueb

GSTP1 Val105Ile
 GSTP1 Ile/Ile 2120.27 (0.19)0.324
 GSTP1 Ile/Val 1390.35 (0.22)0.296
 GSTP1 Val/Val190.59 (0.39)0.034
GSTM1 and GSTP1 Val105Ile
 GSTM1 +/GSTP1 Ile/Ile 96− 0.14 (0.23)0.462
 GSTM1 +/GSTP1 Ile/Val and Val/Val 820.32 (0.26)0.108
 GSTM1 –/GSTP1 Ile/Ile 1260.29 (0.17)0.288
 GSTM1 –/GSTP1 Ile/Val and Val/Val680.67 (0.46)0.044
GSTT1 and GSTP1 Val105Ile
 GSTT1 +/GSTP1 Ile/Ile 1210.20 (0.13)0.142
 GSTT1 +/GSTP1 Ile/Val and Val/Val 890.18 (0.21)0.296
 GSTT1 –/GSTP1 Ile/Ile 1080.39 (0.22)0.103
 GSTT1 –/GSTP1 Ile/Val and Val/Val520.72 (0.58)0.038

a Regression coefficients.
b 𝑃 value were obtained by linear regression after controlling for sex, age, BMI, smoking status and alcohol consumption.

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