Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats

Table 3

Select serum chemistry concentrations (IU/L) of male SD rats following 5 days, 2 weeks, 4 weeks, and 13 weeks of daily exposure of TCP by oral gavage.

Time point	Analyte	TCP dose (mg/kg/day)
		0	10	25	50	100	200
5 Days	ALP^1	621±204^4	515±205	681±212	585±163	610±106	761±178
	ALT^2	40±8	35±10	38±11	41±12	41±20	50±15
	AST^3	118±14	109±36	116±36	118±25	129±33	126±31
2 Weeks	ALP	511±219	537±140	555±146	564±209	566±187	653±120
	ALT	40±13	40±11	52±51	31±11	42±13	68±21^∗∗
	AST	126±56	127±42	137±83	116±51	132±36	144±18
4 Weeks	ALP	407±128	500±140	463±118	489±98	530±180	523±123
	ALT	43±9	39±8	39±9	38±8	47±10	57±10^∗
	AST	122±23	134±20	129±25	119±14	123±11	124±13
13 Weeks	ALP	304±83	295±102	396±153	357±115	425±115	585±127^∗∗
	ALT	38±14	42±9	57±52	61±39^∗	63±29^∗	120±47^∗∗
	AST	125±24	130±17	137±21	152±45	151±22	244±59^∗∗

¹ALP: alkaline phosphatase.
²ALT: alanine aminotransferase.
³AST: aspartate aminotransferase.
⁴mean ± standard deviation for 𝑛=10 except for the following groups: 𝑛=9 (25 and 50 mg/kg/day, 13 weeks); 𝑛=11 (0 mg/kg/day, 5 days, 2 weeks, and 4 weeks); 𝑛=12 (0 mg/kg/day, 13 weeks).
* 𝑃<0.05 compared to control.
** 𝑃<0.01 compared to control.