Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats

Table 1

Group mean feed consumption of male and female rats given Zigbir® daily by gavage for 90 days.

Week	Control and control recovery		250 mg/kg				500 mg/kg				1000 mg/kg and 1000 mg/kg recovery
	Male	Female	Male		Female		Male		Female		Male		Female
0	8.20	6.98	8.25	101%	6.96	100%	7.92	97%	6.68	96%	8.19	100%	6.93	99%
1	11.40	10.21	11.25	99%	10.03	98%	10.85	95%	9.72	95%	10.76	94%	9.10	89%
2	12.22	11.05	12.02	98%	10.85	98%	11.62	95%	10.55	95%	11.57	95%	10.37	94%
3	13.06	11.82	12.89	99%	11.69	99%	12.46	95%	11.37	96%	12.45	95%	11.16	94%
4	13.74	12.60	13.69	100%	12.81	102%	13.27	97%	12.10	96%	13.22	96%	11.96	95%
5	14.64	13.74	14.47	99%	13.64	99%	14.01	96%	12.88	94%	14.06	96%	12.76	93%
6	15.42	14.48	15.21	99%	14.49	100%	14.81	96%	13.59	94%	14.83	96%	13.61	94%
7	16.22	15.27	16.06	99%	15.24	100%	15.67	97%	14.47	95%	15.60	96%	14.41	94%
8	17.03	16.07	16.87	99%	16.05	100%	16.45	97%	15.26	95%	16.41	96%	15.22	95%
9	17.83	16.98	17.69	99%	16.86	99%	17.21	97%	16.05	95%	17.22	97%	15.99	94%
10	18.57	17.68	18.44	99%	17.61	100%	18.05	97%	16.85	95%	18.02	97%	16.88	95%
11	19.45	18.51	19.21	99%	18.45	100%	18.86	97%	17.63	95%	18.80	97%	17.63	95%
12	20.23	19.32	20.01	99%	19.24	100%	19.68	97%	18.43	95%	19.58	97%	18.41	95%
13	21.00	20.13	20.85	99%	20.11	100%	20.51	98%	18.86	94%	20.43	97%	19.19	95%
14	21.92	20.70	—	—	—	—	—	—	—	—	21.20	97%	19.92	96%
15	22.78	21.50	—	—	—	—	—	—	—	—	21.98	96%	20.82	97%
16	23.52	22.40	—	—	—	—	—	—	—	—	22.80	97%	21.54	96%
17	22.98	21.72	—	—	—	—	—	—	—	—	22.38	97%	21.14	97%
Study; average	15.64	14.63	15.49	99%	14.57	100%	15.10	97%	13.89	95%	15.08	96%	13.83	95%
Recovery; average	22.80	21.58	—	—	—	—	—	—	—	—	22.09	97%	20.86	97%

%: percentage of control.