Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats

Table 6

Absolute organ weights (g; mean ± SD) in male rats after 90 days subchronic oral administration of Zigbir®.

Organ	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control recovery	1000 mg/kg recovery
Terminal body weight	348.86 ± 18.31	342.77 ± 28.01	332.90 ± 24.41	339.11 ± 32.83	367.32 ± 29.61	347.08 ± 37.86
Brain	1.978 ± 0.056	1.958 ± 0.059	1.898 ± 0.114	1.961 ± 0.058	1.965 ± 0.165	2.003 ± 0.045
Liver	11.621 ± 1.218	10.544 ± 1.264	10.307 ± 2.068	10.314 ± 1.801	8.769 ± 1.679	9.520 ± 1.092
Kidneys	2.587 ± 0.245	2.498 ± 0.225	2.371 ± 0.300	2.507 ± 0.290	2.472 ± 0.348	2.570 ± 0.237
Adrenals	0.0516 ± 0.009	0.0593 ± 0.009	0.056 ± 0.005	0.0524 ± 0.009	0.0578 ± 0.009	0.0516 ± 0.008
Testes	2.893 ± 0.263	2.834 ± 0.270	3.000 ± 0.341	2.849 ± 0.235	2.647 ± 0.259	2.848 ± 0.401
Heart	1.128 ± 0.100	1.046 ± 0.084	0.996 ± 0.141	1.008 ± 0.121	0.994 ± 0.113	1.057 ± 0.057
Spleen	1.048 ± 0.214	1.126 ± 0.340	1.203 ± 0.351	1.176 ± 0.182	1.086 ± 0.301	1.190 ± 0.235
Lungs	1.606 ± 0.236	1.769 ± 0.217	1.585 ± 0.340	1.612 ± 0.154	1.491 ± 0.261	1.317 ± 0.569