Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats

Table 9

Relative organ weights (% of fasting body weight; mean ± SD) in female rats treated with Zigbir® orally for 90 days.

Organ	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control recovery	1000 mg/kg recovery
Terminal body weight (g)	232.66 ± 11.33	228.66 ± 14.67	216.17 ± 10.90	204.97 ± 6.75	268.78 ± 20.25	255.00 ± 12.83
Brain	0.794 ± 0.056	0.836** ± 0.030	0.836 ± 0.049	0.838 ± 0.018	0.686 ± 0.050	0.716 ± 0.034
Liver	2.995 ± 0.519	3.528 ± 0.231	3.262 ± 0.336	2.979 ± 0.202	3.114 ± 0.304	3.001 ± 0.316
Kidneys	0.693 ± 0.068	0.763 ± 0.072	0.715 ± 0.081	0.712 ± 0.048	0.573 ± 0.081	0.634 ± 0.056
Adrenals	0.0285 ± 0.006	0.0327 ± 0.003	0.0314 ± 0.004	0.0307 ± 0.005	0.0228 ± 0.003	0.028^# ± 0.005
Ovaries	0.0411 ± 0.009	0.047 ± 0.005	0.0437 ± 0.008	0.0466 ± 0.006	0.0541 ± 0.014	0.0588 ± 0.014
Heart	0.329 ± 0.031	0.35 ± 0.028	0.347 ± 0.037	0.359 ± 0.033	0.307 ± 0.036	0.327 ± 0.033
Spleen	0.324 ± 0.071	0.351 ± 0.041	0.435** ± 0.105	0.354 ± 0.049	0.377 ± 0.028	0.341 ± 0.046
Lungs	0.563 ± 0.084	0.695 ±0.163	0.695 ± 0.159	0.642 ± 0.073	0.375 ± 0.037	0.399 ± 0.045
Uterus	0.236 ± 0.071	0.240 ± 0.053	0.263 ± 0.084	0.240 ± 0.043	0.176 ± 0.035	0.205 ± 0.024

∗∗P < 0.01 versus control group.
#P < 0.05 versus recovery control group.