Towards Therapeutic Applications of Arthropod Venom K+-Channel Blockers in CNS Neurologic Diseases Involving Memory Acquisition and Storage

Figure 1

Views of the K_v1.2-𝛽₂ subunit complex. (a) Side view of the K_v1.2-𝛽₂ structure with the extracellular solution above and the intracellular solution below. Four subunits of the channel are colored in yellow (T1 domain and voltage sensor) and green (pore). β subunit tetramer is colored in red. TM indicates the integral membrane component of the complex. (b) Stereoview of a single subunit of the channel and β subunit viewed from the side. Labels correspond to six transmembrane helices (S1 to S6). (c) View of the K_v1.2-𝛽₂ structure from the extracellular side of the membrane. S1–S4 helices from each subunit form four surrounding voltage-sensing domains, S5-S6 regions (green) from the four subunits shape a single pore domain. Purple spheres are potassium ions. Images were generated using Protein Workshop Viewer 3.9 [15] and Protein Data Bank accession ID 2A79 [14].