Short Communication: Is Ethanol-Based Hand Sanitizer Involved in Acute Pancreatitis after Excessive Disinfection?—An Evaluation with the Use of PBPK Model

Table 1

Model parameters for the ethanol PBPK.

Physiological parameters of the model PBPK for ethanol
Body weight	70
Cardiac output (L/h/kg)^0.75	18
Alveolar ventilation (L/h/kg)^0.75	18
Absorbed fraction	0.62
Fraction of cardiac output to each compartment
Fat	0.05
Liver	0.25
Rapidly perfused	0.39
Slowly perfused	0.19
Brain	0.12
Total	1.00
Fraction of body volume compartments
Fat	0.213
Liver	0.0257
Rapidly perfused	0.0443
Slowly perfused	0.607
Brain	0.02
Total	0.91
Physicochemical and metabolic parameters
Partition coefficients
Blood: air	2280
Fat: air	226
Liver: air	1730
Rapidly perfused: air	2030
Slowly perfused: air	1710
Brain: air	1870
Liver metabolic parameter
Metabolism rate (mg/h/kg)^0.75	359.5
Affinity constant (mg/L)	82.1