514068.fig.003a
(a)
514068.fig.003b
(b)
514068.fig.003c
(c)
Figure 3: Cross-eyed stereoscopic drawings of the drugs bound at the antigenic-peptide binding grooves of ADR-associated HLA molecules. The drugs are represented by stick models with carbon atoms and bonds colored in green. The interaction modes of acetaminophen, ibuprofen, and loxoprofen at the peptide-binding groove of the HLA-A*02:06 molecule are shown in (a), (b), and (c), respectively.