Research Article

In Silico Risk Assessment of HLA-A*02:06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients

Figure 3

Cross-eyed stereoscopic drawings of the drugs bound at the antigenic-peptide binding grooves of ADR-associated HLA molecules. The drugs are represented by stick models with carbon atoms and bonds colored in green. The interaction modes of acetaminophen, ibuprofen, and loxoprofen at the peptide-binding groove of the HLA-A*02:06 molecule are shown in (a), (b), and (c), respectively.