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Journal of Toxicology
Volume 2013, Article ID 545802, 11 pages
Research Article

Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan

INRA, TOXALIM (Research Centre in Food Toxicology), UMR 1331, INRA/INP/UPS, 31027 Toulouse, France

Received 13 July 2012; Accepted 20 November 2012

Academic Editor: M. Teresa Colomina Fosch

Copyright © 2013 Cécile Canlet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Like other persistent organochlorine pesticides, endosulfan residues have been detected in foods including fruit, vegetables, and fish. The aim of our study was to assess the impact of a dietary exposure to low doses of endosulfan from foetal development until adult age on metabolic homeostasis in mice and to identify biomarkers of exposure using an 1H-NMR-based metabonomic approach in various tissues and biofluids. We report in both genders an increase in plasma glucose as well as changes in levels of factors involved in the regulation of liver oxidative stress, confirming the prooxidant activities of this compound. Some metabolic changes were distinct in males and females. For example in plasma, a decrease in lipid LDL and choline content was only observed in female. Lactate levels in males were significantly increased. In conclusion, our results show that metabolic changes in liver could be linked to the onset of pathologies like diabetes and insulin resistance. Moreover from our results it appears that the NMR-based metabonomic approach could be useful for the characterization in plasma of a dietary exposure to low dose of pesticide in human.