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Journal of Toxicology
Volume 2013, Article ID 769143, 6 pages
http://dx.doi.org/10.1155/2013/769143
Research Article

Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach

1Physiology Research Center, Kerman University of Medical Sciences, Kerman, P.O.Box 7616914115, Iran
2Department of Physiology and Pharmacology, School of Medicine, Kerman University of Medical Sciences, Kerman, P.O. Box 7616914115, Iran
3Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

Received 26 June 2013; Accepted 4 August 2013

Academic Editor: Michael Cunningham

Copyright © 2013 Siyavash Joukar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

According to the use of Quercus infectoria (QI) and Rosa damascena L. (RD) for therapeutic purposes and lack of adequate information about their cardiovascular effects, we investigated the cardiovascular indices of rabbits which chronically pretreated with these agents. Animal groups were control group (CTL), RD and QI groups with normal chow plus 1.5 g RD and QI extracts, respectively, in each kg of the diet for 45 days; Hyperlipidemic (H) group received high-fat diet for 45 days; H+RD and H+QI groups received high fat diet plus QI and RD extracts, respectively. Blood pressure was greater in H+RD group than CTL, RD, and H groups. Left ventricular developed pressure and left ventricular systolic pressure increased significantly in H+RD group versus CTL and RD groups ( and , resp.) and in H+QI groups ( versus QI groups). Left ventricular end diastolic pressure (LVEDP) showed significant reduction in H+QI group versus H group. QI attenuated the values of total cholesterol, LDL, TG, and atherogenic indices of plasma when coadministrated with a high-fat diet. The results suggest the antilipidemic and antiatherogenic effects of QI. In addition, the use of RD along with a high-fat diet may increase the risk of hypertension in rabbits.