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Journal of Toxicology
Volume 2013, Article ID 802453, 12 pages
http://dx.doi.org/10.1155/2013/802453
Research Article

Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb

1LSU School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA
2Comparative Biomedical Sciences Department, LSU School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA
3Science, Technology and Toxicology (ST&T) Consultants, 655 Montgomery Street, Suite 800, San Francisco, CA 94111, USA
4Division of Biotechnology and Molecular Medicine (BIOMMED), LSU School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA
5Lily of the Desert, 1887 Geesling Road, Denton, TX 76208, USA

Received 6 December 2012; Accepted 30 January 2013

Academic Editor: Steven J. Bursian

Copyright © 2013 Inder Sehgal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy. We tested a decolorized whole leaf (DCWL) aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats. We found this DCWL aloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays. Following acute administration, mice exhibited no adverse signs at 3- or 14-day evaluation periods. When fed to male and female F344 rats over 13 weeks, DCWL aloe led to no toxicity as assessed by behavior, stools, weight gain, feed consumption, organ weights, and hematologic or clinical chemistry profiles. These rats had intestinal mucosal morphologies—examined grossly and microscopically—that were similar to controls. Our studies show that oral administration of this DCWL aloe juice has a different toxicology profile than that of the untreated aloe juice at exposures up to 13 weeks.