Effect of Aqueous Stem Bark Extract of Khaya senegalensis on Some Biochemical, Haematological, and Histopathological Parameters of Rats
Photomicrographs of liver sections, H&E stain 400x. (a) 0 mg/kg bw: normal architecture of the liver: central vein (CV) in the center of the hepatic lobule is filled with blood (B). Hepatocytes, arranged in the form of cords, are rounded in a polyhedral shape and radiate peripherally; they show the nucleus with a clear nuclear membrane and nucleolus (NO); cords are separated by sinusoids (S) with Kupffer cells. (b) 400 mg/kg bw: deranged architecture of the liver, extensive ballooning (BL) of hepatocytes with hyperchromatic nuclei, and nucleoli are not clearly seen; multiple binucleated cells (BN) and sinusoidal arrangement are also deranged, observed centrilobular necrosis (NC). (c) 800 mg/kg bw: distorted architecture of the liver with ballooning degeneration of hepatocytes (H). Observed hyperchromatic nuclei (N) and nucleoli are not clearly seen; multiple binucleated cells (BN) and sinusoidal (S) arrangement also seems to have been deranged. Periportal (PT) inflammation consisting of collection of lymphocytes (L) around the bile duct (BD), portal vein (PV), and hepatic artery (HA). (d) 1200 mg/kg bw: feathery ballooning of hepatocytes with sinusoidal (S) arrangement being deranged; portal triaditis (PT) showing inflammation consisting of a collection of lymphocytes around the bile duct (BD). (e) 1600 mg/kg bw: deranged architecture of liver with hepatocyte vacuolation, ballooning (BL) of hepatocytes with nucleoli not clearly seen, multiple binucleated cells (BN) and sinusoidal arrangement have been deranged; periportal triaditis (PT) showing distorted triads and inflammation consisting of collection of lymphocytes (L) around the hepatic artery (HA), observed hepatic necrosis (NC). (f) 2000 mg/kg: extensive ballooning (BL) of hepatocytes with multiple binucleated dilation with centrilobular necrosis (NC).
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