Table of Contents Author Guidelines Submit a Manuscript
Journal of Toxicology
Volume 2014, Article ID 214574, 5 pages
http://dx.doi.org/10.1155/2014/214574
Clinical Study

Acute Methotrexate Ingestions in Adults: A Report of Serious Clinical Effects and Treatments

1Medical Toxicology, San Antonio Military Medical Center, San Antonio, TX 78234, USA
2San Antonio Military Medical Center, San Antonio, TX 78234, USA
3School of Pharmacy, Concordia University, Mequon, WI, USA

Received 3 February 2014; Accepted 18 March 2014; Published 16 April 2014

Academic Editor: Orish Ebere Orisakwe

Copyright © 2014 Vikhyat S. Bebarta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. W. Smith and L. S. Nelson, “Case files of the New York City Poison Control Center: antidotal strategies for the management of methotrexate toxicity,” Journal of Medical Toxicology, vol. 4, no. 2, pp. 132–140, 2008. View at Google Scholar · View at Scopus
  2. A. Zink, J. Listing, S. Ziemer, and H. Zeidler, “Practice variation in the treatment of rheumatoid arthritis among German rheumatologists,” Journal of Rheumatology, vol. 28, no. 10, pp. 2201–2208, 2001. View at Google Scholar · View at Scopus
  3. M. E. Weinblatt, “Rheumatoid arthritis: more aggressive approach improves outlook,” Cleveland Clinic Journal of Medicine, vol. 71, no. 5, pp. 409–413, 2004. View at Google Scholar · View at Scopus
  4. I. Sinicina, B. Mayr, G. Mall, and W. Keil, “Deaths following methotrexate overdoses by medical staff,” Journal of Rheumatology, vol. 32, no. 10, pp. 2009–2011, 2005. View at Google Scholar · View at Scopus
  5. F. LoVecchio, K. Katz, D. Watts, and I. Wood, “Four-year experience with methotrexate exposures,” Journal of medical toxicology, vol. 4, no. 3, pp. 149–150, 2008. View at Google Scholar · View at Scopus
  6. A. C. Bronstein, D. A. Spyker, L. R. Cantilena, J. L. Green, B. H. Rumack, and S. E. Heard, “2007 Annual report of the American association of poison control centers' National Poison Data System (NPDS): 25th annual report,” Clinical Toxicology, vol. 46, no. 10, pp. 927–1057, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. AAPCC National Poison Data System (NPDS) Reference Manual, Washington, DC, USA, 2007.
  8. T. Sokka, “Increases in use of methotrexate since the 1980s,” Clinical and Experimental Rheumatology, vol. 28, supplement 5, pp. S13–S20, 2010. View at Google Scholar · View at Scopus
  9. A. W. Pruitt, J. M. Kinkade Jr., and J. H. Patterson, “Accidental ingestion of methotrexate,” Journal of Pediatrics, vol. 85, no. 5, pp. 686–688, 1974. View at Google Scholar · View at Scopus
  10. M. Tishler, D. Caspi, B. Fishel, and M. Yaron, “The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients,” Arthritis and Rheumatism, vol. 31, no. 7, pp. 906–908, 1988. View at Google Scholar · View at Scopus