Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats

Table 3

Lipid profile in male rats exposed to 2,5-hexanedione for 21 days.

Endpoints	Control	0.25% 2,5-HD	0.50% 2,5-HD	1.0% 2,5-HD
HDL (mmol/L)	1.15 ± 0.13	0.88 ± 0.03*	0.85 ± 0.13*	0.83 ± 0.12*
LDL (mmol/L)	0.67 ± 0.19	0.93 ± 0.17*	1.19 ± 0.28*	1.35 ± 0.33*
TG (mmol/L)	1.21 ± 0.14	1.49 ± 0.16*	1.52 ± 0.13*	1.57 ± 0.18*
TC (mmol/L)	1.67 ± 0.13	1.99 ± 0.18*	2.33 ± 0.21*	2.37 ± 0.23*
Atherogenic index	0.58 ± 0.05	1.05 ± 0.08*	1.40 ± 0.07*	1.62 ± 0.06*

HDL: high-density lipoprotein; LDL: low-density lipoprotein; TG: triglyceride; TC: total cholesterol; atherogenic index (LDL/HDL). The data are expressed as mean ± SD for eight animals per group. * < 0.05 against control.